发明名称 |
COMBINATION THERAPY USING ANTI-EGFR ANTIBODIES AND ANTI-HORMONAL AGENTS |
摘要 |
The invention relates to a combination therapy for the treatment of tumors a nd tumor metastases, preferably breast and prostate tumors, comprising administration of anti-EGFR (Her1) antibodies and anti-hormonal agents, optionally together with cytotoxic / chemotherapeutic agent. The method and the pharmaceutical compositions comprising said agents can result in a synergistic potentiation of the tumor cell proliferation inhibition effect o f each individual therapeutic agent, yielding more effective treatment than found by administering an individual component alone.
|
申请公布号 |
CA2449166(A1) |
申请公布日期 |
2002.11.14 |
申请号 |
CA20022449166 |
申请日期 |
2002.04.22 |
申请人 |
MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG |
发明人 |
HARSTRICK, ANDREAS;ROSEN, OLIVER |
分类号 |
A61K45/00;A61K31/00;A61K31/565;A61K38/00;A61K39/395;A61P35/00;A61P35/04;A61P43/00;C07K16/28;C07K16/46;(IPC1-7):A61K39/395 |
主分类号 |
A61K45/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|