发明名称 |
Immunoconjugates and methods for their use in tumor therapy |
摘要 |
Novel pH-sensitive immunoconjugates which dissociate in low-pH tumor tissue, comprising a chemotherapeutic agent and an antibody reactive with a tumor-associated antigen are described. The chemotherapeutic agent is coupled to the antibody by a link which is unstable in low pH. The link may comprise a spacer consisting of a polyamino acid. Representative antibodies for use in these immunoconjugates include monoclonal antibodies which are not internalized by tumor cells.
|
申请公布号 |
US5084560(A) |
申请公布日期 |
1992.01.28 |
申请号 |
US19900564387 |
申请日期 |
1990.08.07 |
申请人 |
ONCOGEN |
发明人 |
HELLSTROM, KARL E.;HELLESTROM, INGEGERD E.;LAVIE, EFRAIM |
分类号 |
A61K47/48 |
主分类号 |
A61K47/48 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|