A PHARMACEUTICAL KIT COMPRISING ANTI-HUMAN SEMINAL PLASMA PROTEIN SINGLE CHAIN ANTIBODY/HUMAN CARBOXYPEPTIDASE FUSION PROTEIN AND PRODRUG

摘要

This invention is in the field of antibody-directed enzyme prodrug therapy (ADEPT). More particularly, the invention relates to a kit comprising an anti-human gamma -seminoprotein single-chain antibody ( gamma -Sm scFv)/human carboxypeptidase A(hCPA) fusion protein and a prodrug which is a methotrexate- alpha -peptide. The kit is useful in prostate cancer treatment with the ADEPT. The invention also relates to an anti- gamma -seminoprotein single-chain antibody ( gamma -Sm scFv)/human carboxypeptidase (hCPA) fusion protein.