| 摘要 |
<p>NEW MATERIAL:The compound of formula I (A and B are amino, lower alkylamino, amidino or guanidino; (n) and (m) are 3 or 4; R<1> and R<2> are H, lower alkyl, OH, lower alkyloxy, etc.; R<3> and R<4> are H, lower alkyl, OH, lower alkyloxy, etc.). EXAMPLE:Cyclo(-prolyl-arginyl-prolyl-arginyl-). USE:A therapeutic agent for infectious diseases and autoimmune diseases. PREPARATION:The objective cyclic tetrapeptide of formula I can be produced e.g. by successively bonding amino acids having protected alpha-amino group and side chain functional group from the C-terminal side to a solid carrier in the presence of a condensation agent using a solid-phase process, etc., to synthesize a peptide chain, separating the peptide from the carrier, removing the protecting groups to obtain a tetrapeptide of formula II and cyclizing the compound in the presence of a condensation agent in a solvent.</p> |
