| 摘要 |
Molecular clones of primate lentiviruses that harbor an engineered non-revertible null mutation in the nef gene and which may further include a non-revertible null mutation in one or more of the NRE, vpr, vpx, and/or vpu sequences are disclosed. Intact viruses containing such mutant genomes are also disclosed. These infectious, nonpathogenic viruses are capable of eliciting a protective host immune response and, thus, are useful as a vaccine that protects against AIDS in human subjects. |
