摘要 |
<p>The synthesis and activity of novel LpxA inhibitors is described, these inhibitors present antibacterial activity. The compounds were designed based on a receptor model developed using the crystal structure of LpxA and are arranged to have a favorable binding interaction at the active site of the enzyme. In particular, the compounds present the following formula (I) where V, W, X, Y and Z can be independently C, S, N or O and Pl, P2 and P3 are ligands to bind to the three points of the proposed pharmacophore model. They can be chosen from a variety of groups.</p> |
申请人 |
WU, FAN;WEAVER, DONALD;BARDEN, CHRIS;BYERS, DAVID;MCMASTER, CHRISTOPHER;HENNEBERRY, ANNETTE;BAN, FUQIANG |
发明人 |
WU, FAN;WEAVER, DONALD;BARDEN, CHRIS;BYERS, DAVID;MCMASTER, CHRISTOPHER;HENNEBERRY, ANNETTE;BAN, FUQIANG |