MULTIPARTICULATES OF PREFERABLY AN OPIOID, AND METHOD OF MANUFACTURING USING EXTRUSION

摘要

Extrusion of a mix containing a pharmaceutically active agent can be achieved using a plasticising excipient in an amount sufficient to act as plasticiser and also act as lubricant, thereby avoiding the need for inclusion of a lubricant. The invention provides multiparticulates with controlled release properties, substantially free of lubricant.