METHOD FOR PREPARING N-SUBSTITUTED DERIVATIVES OF 4,6-DIMETHYL-3-CYANOPYRIDYL-2-SULFONYLAMIDES

摘要

FIELD: organic chemistry, chemical technology. ^ SUBSTANCE: invention describes a method for synthesis of N-substituted derivatives of 4,5-dimethyl-3-cyanopyridyl-2-sulfonylamides that can be used as biologically active substances. Method involves preliminary synthesis of 4,6-dimethyl-3-cyanopyridyl-2-sulfonyl chloride by oxidative chlorination of 4,6-dimethyl-3-cyano-(1H)-pyridyl-2-thione without drying step that is subjected for interaction with amine. Interaction with amines is carried out by addition of amine solution in acetone to aqueous suspension of 4,6-dimethyl-3-cyanopyridyl-2-sulfonyl chloride at temperature 8-10°C. Invention provides synthesis of end substances with high yields - 69-74%. N-substituted derivatives of 4,6-dimethyl-3-cyanopyridyl-2-sulfonylamide show antidote activity with respect to herbicide 2,4-D in sunflower seedlings. ^ EFFECT: improved method of synthesis. ^ 3 cl, 8 ex