发明名称 BENZHYDRYL DERIVATIVES HAVING CALMODULIN INHIBITOR PROPERTIES
摘要 The invention relates to a benzhydryl derivative having the formula (I) wherein each of the groups R1, R2, and R3 represents one to four substituents independently selected from the group consisting of hydrogen, lower alkyl, halogen, and CF3, and at least one of the groups R1, R2, and R3 is halogen or CF3; R4 represents hydrogen or methyl; n is 2, 3, or 4; m is 1, 2, or 3; and X represents O or S; or its pharmaceutically acceptable salts. The benzhydryl derivative of the invention can be used to treat patients who are suffering from diseases which are influenced by calmodulin.
申请公布号 CA2046005(A1) 申请公布日期 1992.01.20
申请号 CA19912046005 申请日期 1991.06.28
申请人 AKZO N.V. 发明人 CALDIROLA, PATRICIA;MANNHOLD, RAIMUND;TIMMERMAN, HENDRIK
分类号 A61K31/10;A61K31/135;A61P3/00;C07C211/27;C07C211/28;C07C213/02;C07C217/10;C07C239/04;C07C323/25;(IPC1-7):C07C323/29;C07C217/26 主分类号 A61K31/10
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