COMPUESTOS DERIVADOS DE 2H-ISOQUINOLIN-1-ONA Y 3H-QUINAZOLIN-4-ONA, INHIBIDORES DE CINASA RHO; Y COMPOSICION FARMACEUTICA, UTIL PARA EL TRATAMIENTO DE UNA ENFERMEDAD O AFECCION CARDIOVASCULAR.

摘要

Disclosed are novel substituted 2H-isoquinolin-1-one and 3H-isoquinolin-4-one derivatives useful as inhibitors of Rho kinase and for treating a variety of diseases and disorders that are mediated or sustained through the activity of Rho kinase, including cardiovascular diseases, pharmaceutical compositions comprising such compounds, methods for using such compounds and processes for making such compounds.