| 发明名称 |
ANALOGUES OF PF4 AND FRAGMENTS THEREOF, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| 摘要 |
The subject invention pertains to the use of recombinant PF4 (rPF4) as well as full length novel analogs (mutants) of rPF4, and peptide fragments thereof, to inhibit angiogenesis. rPF4, analogs, and certain fragments are shown to have utility for treating angiogenic diseases and for the inhibition of endothelial cell proliferation. |
| 申请公布号 |
EP0378364(A3) |
申请公布日期 |
1992.01.15 |
| 申请号 |
EP19900300236 |
申请日期 |
1990.01.09 |
| 申请人 |
REPLIGEN CORPORATION |
发明人 |
MAIONE, THEODORE;SHARPE, RICHARD J. |
| 分类号 |
C12P21/02;A61K38/00;A61K38/19;A61P9/00;C07K1/20;C07K1/22;C07K14/52;C12R1/19;(IPC1-7):C07K7/10;C07K7/08;A61K37/02 |
主分类号 |
C12P21/02 |
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