发明名称 |
In vivo panning for ligands to radiation-induced molecules |
摘要 |
A method for identifying a molecule that binds an irradiated tumor in a subject and molecules identified thereby. The method includes the steps of: (a) exposing a tumor to ionizing radiation; (b) administering to a subject a library of diverse molecules; and (c) isolating from the tumor one or more molecules of the library of diverse molecules, whereby a molecule that binds an irradiated tumor is identified. Also provided are therapeutic and diagnostic methods using targeting ligands that bind an irradiated tumor.
|
申请公布号 |
US7402392(B2) |
申请公布日期 |
2008.07.22 |
申请号 |
US20020259087 |
申请日期 |
2002.09.27 |
申请人 |
VANDERBILT UNIVERSITY |
发明人 |
HALLAHAN DENNIS E.;QU SHIMIAN |
分类号 |
G01N33/53;A61K41/00;G01N33/569 |
主分类号 |
G01N33/53 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|