| 摘要 |
PURPOSE: To obtain the subject composition containing specific amounts of an antiallergic agent and an antihistaminic agent, relatively quickly exhibiting the effect without causing serious side actions and useful for the prevention and treatment of allergic reaction in ophthalmic region. CONSTITUTION: This composition contains 0.01-40wt.%, preferably 0.05-3.0wt.% of an antiallergic agent, preferably lodoxamide tromethamine: N,N'-(2-chloro-3- cyano-m-phenylene)dioxaminic acid and 0.01-3.0wt.%, preferably 0.01-2.0wt.% of an antihistaminic agent, preferably pheniramine: N,N-dimethyl-γ-phenyl-2- pyridinopropanamine. The composition is suitable for the treatment of various symptoms of mast cell degranulation and the prevention of allergic inflammation caused by the excretion of histamine by stabilizing the cell of eye or suppressing allergic reaction causing mast cell degranulation and eye stimulation.
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