| 发明名称 |
FREMGANGSMAATE VED FREMSTILLING AV 3'-FLUORPYRIMIDIN-NUKLEOSIDER |
| 摘要 |
<p>An improved process for the synthesis of 3'-fluoropyrimidine nucleosides of the general formula: <CHEM> by reacting a 5'-methanesulfonyl-2'-dideoxy-2,3' -anhydropyrimidine nucleoside at a concentration of up to 20% with hydrogen fluoride in the presence of a suitable aluminum reagent, recovering the 5'-methanesulfonyl-2',3'-dideoxy-3'-fluoropyrimidine nucleoside intermediate by direct crystallization and removing the 5'-methanesulfonyl protecting group in a single step by reaction with an aqueous base solution.</p> |
| 申请公布号 |
NO920180(D0) |
申请公布日期 |
1992.01.14 |
| 申请号 |
NO19920000180 |
申请日期 |
1992.01.14 |
| 申请人 |
AMERICAN CYANAMID COMPANY |
发明人 |
D'ANTUONO III, JOSEPH;BOOP, DONALD CARL;CLAUSS, STEVEN L.;CONSIDINE JR., JOHN LEO;PADMANATHAN, THURAIRAJAH;RIZZO, CARL J.;ANDRADE, JOHN ROBERT |
| 分类号 |
C07H19/073;A61K31/70;A61K31/7042;A61K31/7052;A61K31/7064;A61K31/7072;A61P35/00;C07H19/06;(IPC1-7):C07H/ |
主分类号 |
C07H19/073 |
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