DERIVATIVES OF ASPARTIC ACID AND GLUTAMIC ACID HAVING ANTI-CHOLECYSTOKININ ACTIVITY

摘要

2087193 9200958 PCTABS00010 Cholecystokinin antagonists are provided having formula (I) wherein Ar is (a), (b), (c), (d), (e), (f) or (g) (wherein the aromatic moiety may be substituted or unsubstituted), or (h); R1 is H, C1 to C6 alkyl, C1 to C6 alkenyl, cycloalkyl, -(CH2)qaryl, -(CH2)q(substituted aryl) or -(CH2)qheterocyclic, wherein q is 0 to 4; R2 is H, methyl or ethyl; T is carboxyl, -CONR5R6 (wherein R5 and R6 are independently H or C1 to C4 alkyl) or tetrazolyl; n is 0 to 3, and Q is (i) or (j) wherein X is C1 to C4 alkyl, C1 to C4 alkoxy, C1 to C4 thioalkoxy, carboxy, C1 to C4 carboalkoxy, nitro, trihalomethyl, hydroxy, -NR7R8 (wherein R7 and R8 are independently H or C1 to C4 alkyl), C1 to C4 alkylaryl, C1 to C4 alkyl(substituted aryl) or halo; m is 1 to 3; p is 0 to 3; and R3 is H, C1 to C5 alkyl or -(CH2)rR4 wherein r is 0 to 4 and R4 is aryl or substituted aryl; and pharmaceutically acceptable salts thereof.