| 摘要 |
<p>Various 3-substituted 1-carba(1-dethia)-3-cephems, useful as antibacterial agents are provided. Also provided are pharmaceutical compositions comprising same and methods for treating bacterial infections in man and other animals. An antibacterial compound of the formula <CHEM> wherein R is hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, or C1-C6 haloalkyl; A and A min are independently hydrogen, C1-C6 alkyl, nitro, amino, a 5-6 membered organic heterocycle containing 1, 2 or 3 hetero atoms selected from nitrogen or sulfur, C1-C6 alkoxy or phenyl; or A and A min taken together from a group of the formulae <CHEM> wherein X is hydrogen, halo, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 alkoxycarbonyl, amino, nitro, or carboxy; and Y is nitrogen or carbon; or a pharmaceutically acceptable salt thereof.</p> |
