HUMAN MACROPHAGE INFLAMMATORY PROTEIN 2 alpha

摘要

An attempt to identify the human counterpart of murine macrophage inflammatory protein 2 unexpectedly resulted in not one but two candidate sequences, designated hu-MIP-2 alpha and hu-MIP- beta , respectively. By using the DNA sequences and recombinant systems provided by this invention, one can obtain hu-MIP-2 alpha , one of the two human counterparts to mMIP-2, substantially free of other human protein. This invention also provides antibodies reactive with hu-MIP-2 alpha polypeptides as well as immunoassay methods for determining hu-MIP-2 alpha and nucleotide probes for detecting nucleotide sequences encoding hu-MIP-2 alpha in biological samples.