| 摘要 |
PURPOSE:To industrially advantageously obtain the subject compound by reacting an ethylamine derivative corresponding to the aimed compound with a butane-2-one derivative in the presence of a boron cyanated sodium hydride catalyst and subjecting resultant new intermediate to demethylation. CONSTITUTION:A compound expressed by formula I is reacted with a compound expressed by formula II in an organic solvent, preferably alcoholic solvent, etc., and in the presence of a boron cyanated sodium hydride catalyst to obtain a new substance expressed by formula III. Next, the new substance is subjected to demethylation in a normal method and further an acid is added, as necessary, to afford the aimed compound expressed by formula IV or acid-added salt of the compound useful for treating abruptly depressed cardiac contraction with a few processes and simple and safe process in high yield. Besides, to the compound expressed by formula II, the compound expressed by formula I is preferably used as equimolar to 8 times mol, especially 4-6 times mol and the catalyst is preferably used as equimolar to 5 times mol, especially equimolar to two times mol. |
