发明名称 |
Hidtil ukendte enheder til cancerterapi |
摘要 |
Novel molecular chimaeras produced by recombinant DNA techniques are described. They comprise a target tissue specific transcriptional regulatory sequence (TRS) linked and controlling the expression of a heterologous enzyme for example Varicella Zoster Virus Thymidine Kinase (VZV TK) gene. A molecular chimaera is packaged into a synthetic retroviral particle which is capable of infecting mammalian tissue. This in turn may be administered to a patient, and the TRS will be selectively transcriptionally activated in the target tissue (for example cancerous tissue). Administration of compounds which are selectively metabolised by the enzyme produce cytotoxic or cytostatic metabolites in situ thereby selectively killing or arresting the growth of the target cell. |
申请公布号 |
DK0415731(T3) |
申请公布日期 |
1992.01.08 |
申请号 |
DK19900309430T |
申请日期 |
1990.08.29 |
申请人 |
THE WELLCOME FOUNDATION LIMITED |
发明人 |
KRENITSKY, THOMAS ANTHONY;HUBER, BRIAN;RICHARDS, CYNTHIA ANN |
分类号 |
A61K35/76;A61K38/45;A61K38/46;A61K38/48;A61K38/50;A61K48/00;A61P35/00;C07H19/06;C07H19/16;C07H21/00;C07K14/765;C12N7/01;C12N7/04;C12N9/12;C12N15/54;C12N15/85;C12N15/86;C12N15/867 |
主分类号 |
A61K35/76 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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