ANTIBODIES TO GDF8 AND USES THEREOF

摘要

The disclosure provides novel molecules related to growth and differentiation factor 8 (GDF8), in particular epitopes spe-cific to GDF8 and other specific antagonists of GDF8 in particular anti GDF8 antibodies or antigen binding protein or fragment thereof that may inhibit GDF8 activity and signal in vitro and/or in vivo. The dis-closure also provides for an immunoassay used to detect and quantitate GDF8. The disclosure also provides methods for diagnosing, prevent-ing, ameliorating, and treating GDF8 associated disorders, e.g., de-generative orders of muscle, bone, and insulin metabolism. Finally, the disclosure provides pharmaceuticals for the treatment of such dis-orders by using the antibodies, polypeptides, polynucleotides, and vec-tors of the invention.