发明名称 |
ACTIVATION OF MACROPHAGE TUMORICIDAL ACTIVITY BY GRANULOCYTE-MACROPHAGE COLONY STIMULATING FACTOR |
摘要 |
Macrophages and precursor monocytes are activated to exhibit tumoricidal activity by stimulation solely with granulocyte-macrophage colony stimulating factor. A patient suffering from tumors can be treated by direct administration of therapeutically effective quantities of activated granulocyte-macrophage colony stimulating factor. Homogeneous granulocyte-macrophage colony stimulating factor for use in activating macrophages and monocyte precursors is prepared by recombinant DNA techniques. The gene coding for granylocyte-macrophage colony stimulating factor is isolated and then recombinant protein product expressed in an appropriate expression system. The granulocyte-macrophage colony stimulating factor recovered from the expression system is purified to homogeneity by reverse phase high-performance liquid chromatography.
|
申请公布号 |
US5078996(A) |
申请公布日期 |
1992.01.07 |
申请号 |
US19860888995 |
申请日期 |
1986.07.31 |
申请人 |
IMMUNEX CORPORATION |
发明人 |
CONLON, III, PAUL J.;GRABSTEIN, KENNETH H. |
分类号 |
A61K35/14;A61K35/12;A61K35/26;A61K35/74;A61K38/00;A61K38/16;A61P35/00;C07K14/535;C12N15/00;C12P21/02 |
主分类号 |
A61K35/14 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|