SULFUR-SUBSTITUTED MEVINIC ACID DERIVATIVES

摘要

HX38 SULFUR-SUBSTITUTED MEVINIC ACIDS and pharmaceutically acceptable salts thereof possess activity as cell-selective HMG-CoA reductase inhibitors, thus making them useful as antihypercholesterolemic agents. In the above formula, X is hydrogen or -S(O)m-R1 and Y is hydrogen or S(O)n-R2, except that X and Y are not both hydrogen, or one of X and Y is -S-alkyl-SH and the other is hydrogen; Z is or ; and the remaining symbols are as defined in the specification.