SUBSTITUTED GUANIDINES HAVING HIGH BINDING TO THE

摘要

PCT No. PCT/US91/03594 Sec. 371 Date Jan. 22, 1993 Sec. 102(e) Date Jan. 22, 1993 PCT Filed May 22, 1991 PCT Pub. No. WO91/18868 PCT Pub. Date Dec. 12, 1991The invention relates to a method for the treatment or prophylaxis of psychosis, depression, hypertension, or anxiety in an animal by administering an effective amount of an N,N'-disubstituted guanidine or 2-iminoimadazolidine having an affinity for the sigma receptor. The invention also relates to the novel guanidines of the invention as well as pharmaceutical compositions thereof.