METHOD FOR DIRECT CHEMICAL BINDING OF D-DIMER FROM A BIOLOGICAL SAMPLE FOR DIAGNOSING AND MONITORING THROMBOLYTIC AND HYPERCOAGULABLE STATES

摘要

A method and test kit to perform a simple detection assay for D-dimer, a fibrin breakdown product, which utilizes purified Fragment E of human fibrinogen attached to a solid phase for direct chemical binding of D-dimer from a biological sample. This direct binding method to assay for D-dimer of the present invention can be performed in a number of ways. In one embodiment of the invention, Fragment E is conjugated to latex carrier particles and an agglutination assay performed.