发明名称 |
Cyclic polypeptide with antibiotic activity, process for its preparation and pure culture of a Coelomycetes strain. |
摘要 |
<p>A polypeptide compound of the following general formula : <CHEM> wherein R<1> is hydrogen or acyl group, R<2> is hydroxy or acyloxy, R<3> is hydrogen or hydroxysulfonyloxy, and R<4> is hydrogen or carbamoyl, with proviso that (i) R<2> is acyloxy, when R<3> is hydrogen, and (ii) R<1> is not palmitoyl, when R<2> is hydroxy, R<3> is hydroxysulfonyloxy and R<4> is carbamoyl, and a pharmaceutically acceptable salt thereof, processes for their preparation and pharmaceutical compositions comprising them. The invention relates also to intermediates of the formula <CHEM> wherein R<6> is (C4-C6)alkoxy, higher alkoxy or higher alkenyloxy, and R<7> is -COOH or -SO3H, or its reactive derivative at the carboxy group or a salt thereof and <CHEM> Wherein R<8> is 1 to 4 halogen, and R<9> is lower alkoxy which has one or more halogen, higher alkoxy which has one or more halogen, or its reactive derivative at the carboxy group or a salt thereof. The invention also relates to a biologically pure culture of the microorganism Coelomycetes strain F-11899 (FERM BP-2635).</p> |
申请公布号 |
EP0462531(A2) |
申请公布日期 |
1991.12.27 |
申请号 |
EP19910109856 |
申请日期 |
1991.06.15 |
申请人 |
FUJISAWA PHARMACEUTICAL CO., LTD. |
发明人 |
TOSHIRO, IWAMOTO;AKIHIKO, FUJIE;KUMIKO, NITTA;YASUHISA, TSURUMI;NOBUHARU, SHIGEMATSU;CHIYOSHI, KASAHARA;MOTOHIRO, HINO;MASAKUNI, OKUHARA;KAZUO, SAKANE;KOHJI, KAWABATA;HIDENORI, OHKI |
分类号 |
A61K38/00;A61K38/12;A61P31/04;A61P31/10;C07C309/43;C07K1/06;C07K7/56;C07K7/64;C12P21/04;C12R1/645 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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