发明名称 |
HETEROHYBRIDOMAS PRODUCING HUMAN MONOCLONAL ANTIBODIES TO HIV-1 |
摘要 |
Heterohybridomas producing human monoclonal antibodies against a neutralizing epitope of HIV-1 are prepared by transforming peripheral blood lymphocytes by Epstein-Barr virus, selecting cells producing an antibody to a synthetic peptide representing part of the neutralizing epitope, and fusing them with a heteromyeloma cell. A method for producing a human monoclonal antibody specific for a neutralizing HIV-1 epitope from the heterohybridoma is disclosed, as are human monoclonal antibodies specific for particular peptide epitopes of the V3 loop of the gp120 glycoprotein of HIV. |
申请公布号 |
WO9119797(A1) |
申请公布日期 |
1991.12.26 |
申请号 |
WO1991US04304 |
申请日期 |
1991.06.14 |
申请人 |
NEW YORK UNIVERSITY |
发明人 |
ZOLLA-PAZNER, SUSAN;GORNY, MIROSLAW, K. |
分类号 |
C07K14/16;C07K16/10;C12N5/26 |
主分类号 |
C07K14/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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