摘要 |
This invention relates to new thiophene derivatives having antiinflammatory and analgesic activities and represented by general formula (I), wherein R<1> is hydrogen, halogen, cyano, substituted lower alkyl, substituted or unsubstituted lower alkenyl, acyl, nitro, substituted or unsubstituted amino, sulfo, substituted or unsubstituted sulfamoyl, N-containing heterocyclic sulfonyl, hydroxy, substituted or unsubstituted heterocyclic group, R<2> is substituted or unsubstituted aryl, and R<3> is substituted or unsubstituted aryl, provided that R<3> is aryl substituted with substituent(s) selected from the group consisting of amino, mono(lower)-alkylamino, acylamino, lower alkyl(acyl)amino and sulfamoyl when R<1> is hydrogen, halogen or cyano, and pharmaceutically acceptable salts thereof, to processes for the preparation thereof and to a pharmaceutical composition comprising the same. |