| 摘要 |
Novel compounds selected from the group consisting of: (A) compounds of formula I(1), wherein: one of R<1> and R<2> represents the group (a) and the other represents hydrogen or R<7>CO-; R<5> represents C1 to C6-alkyl or the group -(CH2)n-Z-(CH2)m-Ar; Z represents O, S or -CH2-; n represents an integer of 1 to 8; m represents zero or an integer of 1 to 8; R<7> is C1 to C10 alkyl, C3 to C8 cycloalkyl, aryl, heteroaryl, -N(R<9>R<10>), or R<11>O-; R<3>, R<4>, R<9>, and R<10> are each independently selected from hydrogen, C1 to C6 alkyl and Ar<1>; R<6> and R<11> are each independently C1-C8 alkyl; Ar and Ar<1> are each independently selected from the group consisting of phenyl or substituted phenyl, (B) compounds of formula I(2), wherein: R<5a> represents C1 to C6-alkyl or the group -(CH2)n-Z-(CH2)m-Ar<2>; Ar<2> is selected from the group consisting of phenyl, substituted phenyl, or phenyl optionally substituted by two adjacent groups which together form an additional benzenoid ring; ring Q represents one of the rings Q1, Q2, Q3 or Q4, and pharmaceutically acceptable acid addition salts thereof are described. These compounds possess favorable properties for the treatment of asthma and all types of chronic, obstructionary bronchopulmonary diseases. |
