| 摘要 |
HX10c PHOSPHORUS-CONTAINING HMG-CoA REDUCTASE INHIBITORS AND METHOD Compounds which are useful as inhibitors of cholesterol biosynthesis and thus as hypocholesterolemic agents are provided which have the structure wherein R is OH, or salts thereof ox lower alkoxy; Rx is H or alkyl; R1 is lower alkyl; R2 is lower alkyl; R3 is phenyl or substituted phenyl; and R4 is phenyl or substituted phenyl. New pharmaceutical compositions containing such compounds especially oral dosage forms, and a method for using such compounds to inhibit cholesterol biosynthesis are also provided.
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