| 摘要 |
A compound and process of making thereof of formula <IMAGE> I wherein R1 is hydrogen; and A is alkyl; cycloalkyl; alkenyl; alkyl substituted with trifluoromethyl; phenyl; halophenyl; phenyl-C1-3 alkyl; phenyl-C1-3 alkyl substituted on the phenyl with 1 to 3 substituents selected from the group consisting of halo, C1-3 alkyl, and C1-3 alkoxy; or A is <IMAGE> wherein Z is lower alkyl; R2 is hydrogen or <IMAGE> R3 is hydrogen or methyl, and n is 1 to 5; Y is phenyl, is phenyl substituted by 1 to 3 substituents selected from the group consisting of halo, lower alkyl, and lower alkoxy; Y' is hydrogen or methyl; and b and d are carbon-carbon bonds or c is a carbon-carbon bond; or the corresponding hydroxy acid of formula <IMAGE> II wherein A, and R1, R2, R3, Y and Y' are as described above, or a pharmaceutically acceptable salt of said acid, an alkyl ester of said acid, an acetylamino-substituted-C1-4 alkyl ester of said acid, a phenyl-dimethylamino ester of said acid or a alpha -monoglyceride of said acid, and b and d are carbon-carbon bonds or c is a carbon-carbon bond. The compound of formula I and II are useful in treating hyperproliferative skin diseases, such as psoriasis.
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