发明名称 MELPHALAN DERIVATIVES
摘要 PCT No. PCT/AU86/00392 Sec. 371 Date Dec. 21, 1987 Sec. 102(e) Date Dec. 21, 1987 PCT Filed Dec. 22, 1986 PCT Pub. No. WO87/04154 PCT Pub. Date Jul. 16, 1987.A compound of formula I <IMAGE> Formula I wherein R1 is of formula II <IMAGE> Formula II wherein R4 and R5, which may be the same or different, are bromo, chloro, iodo or alkylsulphonyl; R2 is of formula III <IMAGE> Formula III wherein R6 and R7, which may be the same or different, are H, alkyl, aryl, carboxy, hydroxy or amino and n is 0-10; and R3 is hydroxy or a group capable of being cleared and replaced by a radical having an antigen binding site or R3 is a radical having an antigen binding site.
申请公布号 US5075108(A) 申请公布日期 1991.12.24
申请号 US19870127663 申请日期 1987.12.21
申请人 CONSOLIDATED PHARMACEUTICALS, LIMITED 发明人 MCKENZIE, IAN F. C.;PIETERSZ, GEOFFREY A.;SMYTH, MARK
分类号 C07K14/00;A61K39/00;A61K47/48;C07C67/00;C07C231/00;C07C231/02;C07C231/12;C07C233/47;C07C233/51;C07C235/12;C07C237/12;C07C313/00;C07C317/28;C07K1/113;C07K5/06;C07K19/00 主分类号 C07K14/00
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