POLYPEPTIDE COMPOUND AND A PROCESS FOR PREPARATION THEREOF

摘要

Polypeptide compounds of the following general formula (see formula I) wherein R1 is hydrogen or acyl group, R2 is hydroxy or acyloxy, R3 is hydrogen or hydroxysulfonyloxy, and R4 is hydrogen or carbamoyl, with proviso that (i) R2 is acyloxy, when R3 is hydrogen, and (ii) R1 is not palmitoyl, when R2 is hydroxy, R3 is hydroxysulfonyloxy and R4 is carbamoyl, and pharmaceutically acceptable salts thereof. Also disclosed are the preparation of these compounds, pharmaceutical compositions containing same, and the treatment of infectious diseases using these compounds. These compounds are particularly active against a number of pathogenic microorganisms in humans and animals.