3,4-dihydroisoquinolinylacetic acid derivatives and pharmaceutical composition containing these compounds

摘要

3,4-Dihydroisoquinolinylacetic acid derivatives of the general formula I in which A denotes a benzo or thieno radical; R1 denotes hydrogen, (C1-C10)alkyl, phenyl (C1-C5)alkyl, (C1-C4)alkoxy or -NHCOX (in which X is (C1-C5)alkyl); R5 denotes hydrogen or (C1-C4)alkyl; R4 denotes (C1-C4)alkoxy or an -NR9R10 group, in which R9 and R10 independently of one another denote (a) hydrogen, (b) alkyl, (c) cycloalkyl, (d) dimethylamino, (e) amino (C2-C4)alkyl, (f) phenyl, (g) morpholinyl or (h) pyridinyl, or R9 and R10, together with the nitrogen to which they are bonded, denote a pyrrolidinyl, piperidinyl, morpholinyl or piperazinyl radical, R2, R3, R11 and m see description, and their physiologically acceptable salts with inorganic and organic acids. The compounds have cardioprotective and cerebroprotective action.