发明名称 |
Improved process for the preparation of 2-amino(2,3,5-tri-O-benzyl-beta-D-arabinofuranosyl)adenine. |
摘要 |
<p>A process for the preparation of 2-amino-9-(2,3,5-tri-O-benzyl-beta-D-arabinofuranosyl) adenine (V) is described. The process uses a protected 2,6-di(tri-alkylsilylamino)-9-trialkylsilylpurine (II) which is reacted with protected chlorosugar 2,3,5-tri-O-benzyl-1-chloro-D-arabinofuranose (III) and then the protection groups are removed from the 2 and 6 positions. The process provides a 9-beta-D-arabinofuranosyl-2-fluoroadenine (VII) which is an antileukenine drug.</p> |
申请公布号 |
EP0461407(A1) |
申请公布日期 |
1991.12.18 |
申请号 |
EP19910107780 |
申请日期 |
1991.05.14 |
申请人 |
ASH STEVENS, INC. |
发明人 |
MARKOVAC, ANICA;LAMONTAGNE, MAURICE P. |
分类号 |
C07H19/19;A61K31/70;A61K31/7042;A61K31/7052;A61K31/7076;A61P35/02;C07D473/32;C07F7/10;C07H19/16;C07H23/00 |
主分类号 |
C07H19/19 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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