| 摘要 |
The solution concerns a method of production of compound of general formula I, where R<1> and R<2> always mean hydrogen, C1-4-alkyl, possibly substituted in position 1, or C1-4-fluoroalkyl, provided that at least one of the R<1> and R<2> symbols mean hydrogen, R<3> is C1-4-alkyl, or possibly substituted benzyl and the value of n is from 2 to 6, and their pharmaceutically applicable addition salt with acids, characteristic by the fact that the mixture of tertiary amine or sterically protected secondary amine and compound reacts with phosphorohalogenidate and the originated intermediary enol-phosphate is treated by thioalkylamine and the resulting compound is isolated in free form or in the form of salts. The produced compounds can be used as antibiotics or as intermediary products for preparation of other carbapenemic antibiotics.<IMAGE>
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