| 摘要 |
Compounds of general formula I, <IMAGE> I wherein: A represents (CH2)m optionally substituted by R3, B represents (CH2)n optionally substituted by R4, R1 represents hydrogen, C1-C6 alkyl, C1-6 alkenyl or C1-6 alkynyl, R2 represents hydrogen, C1-C6 alkyl or COOR5, in which R5 represents C1-C6 alkyl, R3 and R4 independently represent hydrogen or C1-C6 alkyl, in addition, any two of R2, R3 and R4 may together form a C1-3 alkylene chain, n and m independently represent an integer from 1-3 inclusive, Y represents O or S, and pharmaceutically acceptable acid addition salts thereof are useful as pharmaceuticals, in particular as central muscarinic acetylcholine receptor agonists. The compounds are therefore useful in the treatment of diseases such as presenile and senile dementia, Huntington's chorea, tardive dyskinesia, hyperkinesia, mania and Tourette Syndrome.
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