发明名称 |
ERGOLINE DERIVATIVES |
摘要 |
An ergoline derivative of the formula I: I wherein R1 represents hydrogen or a methyl group; R2 represents hydrogen or a halogen atom, a methyl, cyano or phenyl group or an alkylthio group having from 1 to about 4 carbon atoms; R3 represents a hydrocarbon group having from 1 to about 4 carbon atoms; R4 represents hydrogen, a phenyl group or a hydrocarbon group having from 1 to about 4 carbon atoms; wherein either (a) R6 and R7 represent a valence bond or hydrogen atoms and R8 represents a hydrogen atom or a methoxy group, or (b) R6 represents a hydrogen atom and R7 and R8 taken together represent a valence bond; W represents an oxygen atom or an imino group; A represents a group of 25521-141 the formula CHR5, CH=CR5 or CH2CHR5 wherein R5 represents a hydrogen atom or an alkyl group having from 1 to about 4 carbon atoms; X represents an oxygen or sulphur atom or an imino group; and n is 0, 1 or 2; or a pharmaceutically acceptable salt thereof. These compounds are useful as antihypertensive agents. |
申请公布号 |
CA1293247(C) |
申请公布日期 |
1991.12.17 |
申请号 |
CA19880570065 |
申请日期 |
1988.06.22 |
申请人 |
FARMITALIA CARLO ERBA S.R.L. |
发明人 |
MANTEGANI, SERGIO;BRAMBILLA, ENZO;TEMPERILLI, ALDEMIO;RUGGIERI, DANIELA;SALVATI, PATRICIA |
分类号 |
A61K31/48;A61P9/12;C07D457/02;C07D457/12 |
主分类号 |
A61K31/48 |
代理机构 |
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代理人 |
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主权项 |
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