发明名称 |
PYRIMIDINE NUCLEOSIDE DERIVATIVES |
摘要 |
The pyrimidine compounds of the present invention are represented by the general formula: and pharmaceutically-acceptable salts thereof. In the above formulae, R1 represents a hydroxyl group or an amino group which may be substituted by an acyl group; R2 represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms; R3 represents a hydrogen atom or a hydroxyl group; and R4 and R5 each represent a hydrogen atom or together may form a group -R6R7Si-O-SiR6'R7'- (wherein R6, R7, R6' and R7' may be the same or different from one another and each represents an alkyl group having 1 to 4 carbon atoms). The compounds of the present invention exhibit excellent antitumor effect or are intermediates for synthesizing useful antitumor agents. |
申请公布号 |
CA2085345(A1) |
申请公布日期 |
1991.12.16 |
申请号 |
CA19912085345 |
申请日期 |
1991.06.13 |
申请人 |
SANKYO COMPANY, LIMITED |
发明人 |
UEDA, TOHRU (DECEASED);UEDA, SUMIKO;UEDA, MASATO;UEDA, NOZOMI;UEDA, HIROMI;MATSUDA, AKIRA;SASAKI, TAKUMA |
分类号 |
A61K31/505;A61K31/70;A61K31/7042;A61K31/7052;A61K31/7064;A61K31/7068;A61K31/7072;A61K31/7135;A61P35/00;C07D405/04;C07F7/18;C07H19/06;C07H19/067;C07H19/16;C07H23/00 |
主分类号 |
A61K31/505 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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