| 摘要 |
<p>This invention provides an isolated nucleic acid molecule encoding a wild-type animal protein associated with neuronal degeneration and an isolated nucleic acid molecule encoding a mutated animalprotein associated with neuronal degeneration. Also provided are strains of the nematode Caenorhabditis elegans containing the nucleic acid molecules encoding a mutated C. elegans protein associated with neuronal degeneration. The invention also provides methods for detecting such nucleic acid molecules, for diagnosing degenerative disease, for causing a diseased human cell to degenerate, and for screening drugs to identify drugs which prevent or decrease neuronal degeneration.</p> |
