发明名称 |
ANTISENSE INHIBITORS OF THE HUMAN IMMUNODEFICIENCY VIRUS |
摘要 |
Methods for modulating the expression of the HIV tat gene are disclosed comprising contacting tat RNA with oligonucleotide or oligonucleotide analog which can bind with at least a portions of the RNA. In accordance with the preferred embodiments, oligonucleotides or oligonucleotide analogs are designed to bind to portions of the tat RNA which are of significance to the expression of the gene coding for said RNA. In accordance with a preferred embodiment, methods of treatment of human immunodeficiency virus are disclosed. |
申请公布号 |
AU7882691(A) |
申请公布日期 |
1991.12.10 |
申请号 |
AU19910078826 |
申请日期 |
1991.04.22 |
申请人 |
ISIS PHARMACEUTICALS, INC. |
发明人 |
DAVID J ECKER |
分类号 |
A61K48/00;A61K38/00;A61P31/12;C07H21/04;C07K14/16;C12N15/09;C12N15/113 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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