发明名称 |
Genes encoding a 3-acylation enzyme for macrolide antibiotics. |
摘要 |
A DNA fragment or a restriction enzyme-digested DNA fragment, the DNA fragment containing a gene, acyA, encoding a 3-acylation enzyme for macrolide antibiotics, characterized by being derived from a strain belonging to the genus Streptomyces, having a size of about 1.8 kb or about 3.2 kb, and having a DNA base sequence shown in a restriction enzyme map shown in Fig. 1(A) or Fig. 1(B), respectively, in the attached drawing. 3-Acylated macrolide antibiotics can be produced advantageously using macrolide antibiotics-producing bacteria transformed with vector plasmids having inserted therein the DNA fragment. |
申请公布号 |
EP0459525(A2) |
申请公布日期 |
1991.12.04 |
申请号 |
EP19910109033 |
申请日期 |
1991.06.03 |
申请人 |
MERCIAN CORPORATION |
发明人 |
ARISAWA, AKIRA;KAWAMURA, NAOTO;KOJIMA, IKUO;TONE, HIROSCHI;OKAMOTO, ROKURO;OKAMURA, KAZUHIKO |
分类号 |
C07H17/08;C12N1/21;C12N9/10;C12N15/55;C12N15/76;C12P19/62 |
主分类号 |
C07H17/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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