发明名称 QUINOLINOXY PHENYLSULPHONAMIDES
摘要 New phenylsulphonamide of the formula in which <IMAGE> (I) R1 represents a pyridyl, quinolyl or isoquinolyl radical which is unsubstituted or substituted by halogen, alkyl, cycloalkyl, alkoxy, cyano, nitro, halogenoalkyl, halogenoalkoxy, alkoxycarbonyl or alkylsulphonyl, R2 represents hydrogen, cyano, nitro, halogen, alkyl, alkoxy, halogenoalkyl, halogenoalkoxy or alkoxycarbonyl, R3 represents an aryl radical which is unsubstituted or monosubstituted, disubstituted or trisubstituted by halogen, halogenoalkyl, halogenoalkoxy, alkyl, alkoxy, alkylthio, alkylsulphonyl, cyano, nitro or alkoxycarbonyl, the substituents being identical or different, or represents pentafluorophenyl or represents a straight-chain, branched or cyclic alkyl which is unsubstituted or substituted by halogen, aryl, aryloxy, cyano, alkoxycarbonyl, alkoxy, alkylthio or trifluoromethyl, and X represents an -O-, -A-B- or -B-A- group where A denotes -O-, <IMAGE> and B denotes -CH2- or <IMAGE> where R1 does not represent a pyridyl radical when x represents an -O- group, and salts thereof are prepared by reacting appropriate amines with sulphonyl halides. The substituted phenylsulphonamides can be employed as active compounds for inhibiting enzymatic reactions and for inhibiting thrombocyte aggregations.
申请公布号 US5070096(A) 申请公布日期 1991.12.03
申请号 US19900614329 申请日期 1990.11.15
申请人 BAYER AKTIENGESELLSCHAFT 发明人 MOHRS, KLAUS;PERZBORN, ELISABETH;SEUTER, FRIEDEL;FRUCHTMANN, ROMANIS;KOHLSDORFER, CHRISTIAN
分类号 A61K31/44;A61K31/4402;A61K31/4418;A61K31/47;A61K31/472;A61P3/00;A61P7/02;A61P9/08;A61P9/10;A61P29/00;A61P37/08;C07D213/38;C07D213/74;C07D215/12;C07D215/14;C07D215/20;C07D215/22;C07D215/227;C07D215/26;C07D215/38;C07D217/02;C07D217/14;C07D217/22 主分类号 A61K31/44
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