| 摘要 |
4-18105/A HIV protease inhibitors and processes for their preparation The invention relates to compounds of formula (I), wherein R1 is di-lower alkylamino, pyrrolidino, piperidino, morpholino, thiomorpholino, S,S-dioxothiomorpholino, piperazino, N-lower alkylpiperazino, benzyloxy or benzyloxy substituted in the phenyl ring by lower alkyl or by lower alkoxy, A1 is a bivalent radical of one of the amino acids valine and asparagine that is bonded N-terminally to the group -(C=0) and C-terminally to the group -NH, A2 is a bivalent radical of one of the amino acids tyrosine and phenylalanine that is bonded N-terminally to the group -(C=0) and C-terminally to the group -NH, and R3 is OR2 or NHR2 wherein R2 is hydrogen or lower alkyl, and also to salts of those compounds insofar as one or more salt-forming groups is (are) present. The compounds are gag protease inhibitors and are suitable for the treatment of retroviral diseases.
|
