COMPUESTOS DE 6ALFA-CLORO, BROMO O YODO (R)-6BETA (1'(R)-HIDROXI-ETILPENICILINA, UTILES COMO INTERMEDIARIOS PARA LA SISTENSIS DE ANTIBIOTICOS CARBAPENEM Y PENEM Y PROCEDIMIENTO PARA PREPARARLOS.

摘要

A novel stereocontrolled process is disclosed for converting 6-aminopenicillanic acid to an optically active azetidinone of the formula wherein R'' is a hydroxy-protecting group by use of a 6,6-dihaloanhydropenicillin or 6,6-bis(phenylselenyl)anhydropenicillin intermediate.