PROCESS FOR THE PRODUCTION OF MEDICAL PREPARATIONS FOR DECREASING HEART-FIBRILLATION

摘要

Compounds of the formula I: and tautomers thereof, wherein at least one of R2, R3 and R4 is a strong electron withdrawing group, are disclosed. These compounds possess potassium channel activating activity and, as such, are useful as antihypertensive agents and show less cardiac effects than known potassium channel activators. Also disclosed is a process for preparing these and other compounds and the use of potassium channel activators for the preparation of drugs for the treatment of fibrillation of the heart wherein said potassium channel activators are selected from pinacidil, cromakalim, nicorandil, minoxidil and the compounds of formula I.