发明名称 |
7-(DIPHENYLMETHYL)OXY-9A-METHOXYMITOSANE AND MAKING AND USE THEREOF |
摘要 |
7-(Diphenylmethyl)oxy-9a-methoxymitosane is a novel intermediate for conversion into 7-amino and 7-oxy-9a-methoxymitosanes and is also useful for inhibiting mammalian tumor growth. The compound is prepared by reacting 7-hydroxy-9a-methoxymitosane with diazodiphenylmethane. In a preferred reaction, the compound is prepared from mitomycin C via 7-hydroxy-9a-methoxymitosane without drying (water removal). The intermediate is advantageously converted to the very effective anti-tumor agent 7-[2-(4-nitrophenyldithio)ethylamino]-9a-methoxymitosane in unexpectedly high yields using a two step process where the first step constitutes conversion to 7-[2-(2-pyridyldithio) ethylamino]-9a-methoxymitosane or 7-[2-(3-nitro-2-pyridyldithio)ethylamino]-9a-methoxymitosane. |
申请公布号 |
ZA9101672(B) |
申请公布日期 |
1991.11.27 |
申请号 |
ZA19910001672 |
申请日期 |
1991.03.07 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
DANIEL A. BENIGNI;KENTON L. SHULTIS;HENRY SHE LAI WONG |
分类号 |
A61K31/40;A61K31/00;A61K31/407;A61P35/00;C07D487/14 |
主分类号 |
A61K31/40 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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