发明名称 |
Process for the preparation of lactam derivatives. |
摘要 |
<p>The invention relates to a process for the preparation of a compound of formula (I) <CHEM> wherein R represents a hydrogen atom or a methyl or ethyl group, which comprises cyclising a compound of formula (IV) <CHEM> Where R represents a hydrogen atom, the compound of formula (IV) may optionally be alkylated to produce a compound in which R is methyl or ethyl. The compound of formula (I) is useful as an intermediate in the preparation of 2,3,4,5-tetrahydro-2-[(imidazol-4(or5)-yl)methyl]-1H-pyrido[4,3-b]indo l-1-ones having 5-HT3 antagonist activity.</p> |
申请公布号 |
EP0458624(A1) |
申请公布日期 |
1991.11.27 |
申请号 |
EP19910304642 |
申请日期 |
1991.05.22 |
申请人 |
GLAXO GROUP LIMITED |
发明人 |
WHITEHEAD, JOHN WILLIAM FRANK;MILLS, KEITH;COATES, IAN HAROLD;OXFORD, ALEXANDER WILLIAM;NORTH, PETER CHARLES |
分类号 |
C07B61/00;C07D211/86;C07D471/04 |
主分类号 |
C07B61/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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