| 摘要 |
2062758 9118618 PCTABS00008 Immunotherapeutic, prophylactic and diagnostic compositions useful in treating or preventing diseases in humans caused by infective agents whose primary targets are T4+ lymphocytes, including acquired immune deficiency syndrome, AIDS related complex and human immunodeficiency virus infection. DNA sequences that code for amino acid variants and derivatives of human CD4, or fragments thereof, that elicit in a human antibodies that bind to HIV gp120. Such DNA sequences are useful in the immunotherapeutic, prophylactic and diagnostic compositions of this invention. A novel screening method for selecting amino acid variants and derivatives of human CD4 that elicit in humans antibodies that bind to HIV gp120, human CD4, or both, useful as therapeutic, prophylactic and diagnostic agents for diseases caused by infective agents whose primary targets are T4+ lymphocytes, including acquired immune deficiency syndrome, AIDS related complex and human immunodeficiency virus infection.
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