| 摘要 |
NEW MATERIAL:A compound of formula I [R<1>, R<2>, R<4> are H, lower alkyl; R<3> is H, halogen; X is -OCO-, a group of formula II (R<5> is H, lower alkyl), -CO-; n is 0, 1; Y is alkyl, alkinyl, NC-(CH2)p-(p is 1-6), A-(CH2)4-(A is cycloalkyl, morpholino, etc.; q is 0-6), etc.,]. EXAMPLE:2-[4-(1-Benzyloxycarbonyl)piperidyl]-4-(2-chlorophenyl)-9-meth yl-6H- thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine of formula III. USE:An anti-PAF (blood platelet-activating factor) agent. PREPARATION:A compound of formula IV is condensation-reacted with a compound of formula V in an inactive solvent such as chloroform preferably at 100-130 deg.C. |
