| 摘要 |
NEW MATERIAL: A compound represented by formula I [R<6> is a 1-6C alkyl; X is CR<5> ; Y is CH; R<1> is NO2 , NH2 or NHCOR<8> (R<8> is a 1-6C alkyl); R<2> and R<3> are each H or a 1-6C alkyl which is substituted with (SO3 H), piperazyl, piridyl, etc.), with the proviso that R<2> and R<3> are not simultaneously H; either one of R<4> and R<5> is H, a 1-6C alkyl or a 1-6C alkoxy and the other is H, a 1-6C alkyl or R<14> Z (R<14> is a 1-6C alkyl or phenyl; Z is O or S)]. EXAMPLE: N-Methoxycarbonyl-N'-[2-(N'-cyano-N"-methylguanidino)-ethyl]-N"-(2- nitro-4-propylthiophenyl)guanidine. USE: The antiparasitic medicinal composition is useful for exterminating intestinal parasites. PREPARATION: For example, a compound of formula II is reacted with a compound of formula III in a reactive solvent to provide a compound of formula I. |
